Seagen

Research Associate III, Cell Line Generation

Description

Summary

We are seeking a highly capable laboratory-based Research Associate III with a technical background in cell line engineering. This scientist will be a part of the Antibody Discovery team, generating therapeutic antibodies for tumor-directed antibody-drug conjugates (ADCs). The primary responsibility will be designing and generating cell lines and associated assays for antibody characterization. The candidate should work well within a highly collaborative team environment, while being able to work independently to design, execute, troubleshoot, optimize, and interpret experiments. Specific position level will be commensurate with applicant’s experience.

Principal Responsibilities:

• Contribute intellectually and experimentally to the discovery and validation of potential new oncology drug candidates
• Collaborate on the design of antibody campaigns and the selection strategy for lead biologics
• Utilize molecular biology concepts to design constructs for use in cell line generation, including transfection, CRISPR/Cas9 tools, and lentiviral transduction
• Design, execute, troubleshoot, optimize, and interpret experiments related to stable cell line generation
• Evaluate target expression and antibody specificity by flow cytometry
• Design and optimize cell-based assays for lead antibody characterization, which may include internalization, function modulation, or ligand blocking
• Coordinate workflows with cross-functional teams, project leads, and CROs
• Keep detailed and accurate laboratory records, communicate results in written and oral format, and present results at group meetings and cross-departmental meetings

Qualifications:

• A./B.S. or M.A./M.S. in cellular biology, molecular biology, biochemistry, or relevant field
• 3-5+ years of experience in an academic, biotech, or pharmaceutical research setting
• Requires 1+ years of experience in vector design and cell line engineering
• Preference for candidates with experience in multicolor flow cytometry, cell-based assay development, and high throughput applications
• Demonstrated ability to work both independently and as part of a team in a fast-paced, dynamic environment while handing multiple projects simultaneously
• Strong desire for continued learning
• Ability to generate high quality documentation and communicate effectively to a variety of audiences through oral and written formats
• Team player and solution-oriented, with strong analytical, interpersonal, organizational and time-management skills

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

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Seagen

Seagen is an Equal Opportunity Employer

Submitted: 04/02/2021